Peg Mgf Product Description Essay - 1451 Words

PEG-MGF: Product Description PEG-MGF (PEGylated Mechano Growth Factor) is an analogue of the insulin-like growth factor (IGF-1). It initiates the division of myoblasts and enables the fusing and maturation of muscle fibers, a process that is crucial in the growth of adult muscle. The variation between MGF and IGF-1 is as a result of the MGF property to stimulate division of myoblasts by stimulating a set of different receptors. The synthetic MGF (PEG-MGF) peptide is water soluble and after intramuscularly administration it ends up in the bloodstream. On the other hand, natural MGF is locally synthesized and does not get into the bloodstream. MGF has a very short stability period as it breaks down rapidly once introduced in the body and hence the synthetic peptide is PEGylated to ensure it is not broken down when in the bloodstream hence retaining its bioactivity and efficiency. PEGylation is the joining of a Polyethylene glycol (PEG) structure with a larger molecule. As such, the PEG serves as a protective coat ing to the MGF molecule. PEG-MGF is therefore a combination of Polythylene glycol and MGF (Mechano Growth Factor). The molecular mass for PEG-MGF is 2867.2 and its molecular formula is C121H200N42O39. The molecular sequence of PEG-MGF is PEG-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-NH2. PEGylated MGF has a relatively higher bioavailability and has an extended half-life. Product History PEG-MGF was developed as a